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Related Concept Videos

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Related Experiment Video

Updated: Jul 26, 2025

Induction and Analysis of Oxidative Stress in Sleeping Beauty Transposon-Transfected Human Retinal Pigment Epithelial Cells
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How Oxidative Stress Induces Depression?

Na Ji1, Mengzhu Lei1, Yating Chen1

  • 1The School of Public Health, Faculty of Basic Medical Sciences, Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin Guangxi, China.

ASN Neuro
|June 18, 2023
PubMed
Summary
This summary is machine-generated.

Oxidative stress (OS) plays a key role in depression pathogenesis. Understanding OS-induced pathways, like mitochondrial dysfunction and neuroinflammation, offers new therapeutic targets for effective depression treatment.

Keywords:
BDNF/TrkB dysfunctiondepressionglutamate excitotoxicitymicrobiota disturbanceneuroinflammationoxidative stress

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • Depression is a global health issue with complex pathogenesis.
  • Current antidepressants targeting monoamine systems have limitations like slow onset and treatment resistance.
  • Novel antidepressants like esketamine target the glutamatergic system but have side effects.

Purpose of the Study:

  • To explore novel depression pathogenesis involving oxidative stress (OS).
  • To elucidate the downstream pathways of OS-induced depression.
  • To identify new therapeutic targets for safer and more effective depression treatments.

Main Methods:

  • Review of accumulating clinical and animal studies.
  • Summary and exposition of OS downstream pathways.
  • Elaboration on molecular mechanisms and interactions between pathways.

Main Results:

  • Oxidative stress is critically involved in depression.
  • Key downstream pathways include mitochondrial impairment, neuroinflammation, glutamate excitotoxicity, BDNF/TrkB dysfunction, serotonin deficiency, microbiota-gut-brain axis, and HPA axis dysregulation.
  • Intricate interactions and molecular mechanisms mediating these pathways were analyzed.

Conclusions:

  • Oxidative stress is a significant factor in depression.
  • Understanding OS-induced pathways provides insights into depression mechanisms.
  • This review offers potential novel targets for developing more effective and safer depression therapies.