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Relationship between gluten availability and celiac disease prevalence: A geo-epidemiologic systematic review
Claire L Jansson-Knodell1, Melis G Celdir2, Isabel A Hujoel3
1Division of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Gluten-containing grain availability shows mixed associations with celiac disease prevalence. Higher wheat intake correlates with increased risk, while barley and rye show protective effects in this global study.
Area of Science:
- Epidemiology
- Gastroenterology
- Genetics
Background:
- Celiac disease is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals.
- The global impact of gluten-containing grain availability on celiac disease prevalence remains unclear.
- Understanding these associations is crucial for public health strategies.
Conclusions:
- Gluten-containing grain availability exhibits complex associations with celiac disease prevalence.
- Wheat consumption may increase risk, whereas barley and rye appear protective.
- Further research is needed to elucidate the intricate relationship between diet, genetics, and celiac disease.
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