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Emerging roles of circ_NRIP1 in tumor development and cancer therapy (Review)

Xin Gao1, Yongbo Yu1, Haicun Wang1

  • 1General Surgery Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China.

Oncology Letters
|June 19, 2023
PubMed

Insights

Circular RNA nuclear receptor interacting protein 1 (circ_NRIP1) is highly expressed in tumors and drives cancer progression. This review explores circ_NRIP1

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are non-coding RNA molecules involved in crucial biological processes.
  • Aberrant circRNA expression is linked to various human cancers.
  • CircRNA nuclear receptor interacting protein 1 (circ_NRIP1) is implicated in tumor development.

Purpose of the Study:

  • To review the expression patterns of circ_NRIP1 in diverse malignant tumors.
  • To highlight the role of circ_NRIP1 in cancer progression and development.
  • To explore the potential of circ_NRIP1 as a cancer biomarker and therapeutic target.

Main Methods:

  • Literature review of studies on circ_NRIP1 expression and function in cancer.
  • Analysis of circ_NRIP1 abundance in various human tumor types compared to normal tissues.
  • Synthesis of evidence regarding circ_NRIP1's influence on tumor cell proliferation, invasion, and migration.

Main Results:

  • circ_NRIP1 is frequently overexpressed in multiple human cancers.
  • Higher circ_NRIP1 levels correlate with advanced tumor progression and poor prognosis.
  • circ_NRIP1 promotes malignant behaviors including proliferation, invasion, and migration.

Conclusions:

  • circ_NRIP1 represents a significant factor in cancer development and progression.
  • circ_NRIP1's aberrant expression and functional roles suggest its potential as a diagnostic biomarker.
  • circ_NRIP1 may serve as a novel therapeutic target for cancer treatment.
Keywords:
circular RNAcircular RNA nuclear receptor interacting protein 1therapeutic potentialtumor development

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