Related Experiment Video
Updated: Jul 26, 2025

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Nelson's Syndrome: A Narrative Review.
Jorge Alejandro Torres-Ríos1, Gerardo Romero-Luna1, Juan Marcos Meraz Soto1
1Neurosurgery and Radiosurgery, National Institute of Neurology and Neurosurgery, Mexico City, MEX.
Nelson's syndrome (NS) is a rare complication after Cushing's disease treatment. This review covers its characteristics, diagnosis challenges, and treatment controversies, including stereotactic radiosurgery.
Area of Science:
- Endocrinology
- Oncology
- Neurosurgery
Background:
- Nelson's syndrome (NS) is an uncommon complication following bilateral adrenalectomy for persistent Cushing's disease.
- Pathophysiology remains poorly understood, with an incidence of 1.8–2.6 cases per million annually.
- NS presents with hyperpigmentation, elevated ACTH, and pituitary adenoma symptoms.
Purpose of the Study:
- To provide a comprehensive overview of Nelson's syndrome.
- To discuss diagnostic challenges and treatment complexities.
- To review the role of stereotactic radiosurgery in NS management.
Main Methods:
- Literature review of Nelson's syndrome.
- Analysis of clinical characteristics and pathophysiology.
- Evaluation of diagnostic criteria and therapeutic strategies.
Main Results:
- NS is characterized by hyperpigmentation, elevated ACTH, and pituitary mass effects.
- Diagnostic criteria are not universally accepted, complicating management.
- Stereotactic radiosurgery is a controversial yet essential treatment option.
Conclusions:
- Nelson's syndrome poses significant clinical challenges due to diagnostic and therapeutic complexities.
- Further research is needed to elucidate NS pathophysiology.
- Stereotactic radiosurgery represents a key, albeit debated, therapeutic modality for NS.
More Related Videos
05:44Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
Published on: May 17, 2024
08:22A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
Published on: December 1, 2017
Related Concept Videos
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome II : Assessment and Medical Management
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
Acute Coronary Syndrome V: Nursing Management
Nephrotic Syndrome III : Nursing Management
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...