The role of monocytes in thrombotic diseases: a review

Area of Science:

• Cardiovascular and cerebrovascular diseases research
• Immunology and thrombosis
• Innate immunity and cardiovascular health

Background:

• Cardiovascular and cerebrovascular diseases are leading causes of mortality, with thrombotic events being the most frequent.
• Thrombosis can precipitate life-threatening conditions like acute coronary syndrome and cerebral infarction.
• Circulating monocytes, crucial for innate immunity, also play a role in coagulation and anticoagulation processes.

Purpose of the Study:

• To review the intricate relationship between distinct monocyte subsets and cardiovascular thrombotic events.
• To elucidate the specific roles of monocytes in arterial thrombosis and their involvement in intravenous thrombolysis.
• To summarize current understanding of monocyte-thrombosis mechanisms and therapeutic approaches in various cardiovascular conditions.

Main Methods:

• Literature review focusing on monocyte subsets and thrombotic events.
• Analysis of monocyte functions in arterial thrombosis and thrombolysis.
• Synthesis of data on monocyte-thrombosis interplay in specific diseases.

Main Results:

• Monocytes are increasingly recognized for their significant involvement in thrombosis and immune-related thrombotic diseases.
• Specific monocyte subsets demonstrate distinct roles in the pathogenesis of cardiovascular thrombotic events.
• Mechanisms linking monocytes to thrombosis in conditions like hypertension and atherosclerosis are being uncovered.

Conclusions:

• Monocyte subsets are critical players in the development and progression of cardiovascular thrombotic events.
• Targeting monocyte pathways presents a promising avenue for novel therapeutic interventions against thrombosis.
• Further research into monocyte-thrombosis mechanisms is essential for developing effective treatment regimens.