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Updated: Jul 26, 2025
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Comparison of Monopolar Review to Fixed Parameter Fractionation in Deep Brain Stimulation
John A Thompson1,2, Lisa Hirt2, Pamela David-Gerecht2
1Department of Neurology University of Colorado School of Medicine Aurora Colorado USA.
Background:
Technological advancements in deep brain stimulation (DBS) require methodological changes in programming. Fractionalization poses significant practical challenges for the most common approach for assessing DBS efficacy, monopolar review (MR).
Objectives:
Two DBS programming methods: MR and fixed parameter vertical and horizontal fractionalization (FPF) were compared.
Methods:
A two-phase process of vertical and horizontal FPF was performed. MR was conducted thereafter. After a short wash-out period, both optimal configurations determined by MR and FPF were tested in a double-blind randomized manner.
Results:
Seven PD patients were enrolled, providing 11 hemispheres to compare the two conditions. In all subjects, the blinded examiner selected a directional or fractionalization configuration. There was no significant difference in clinical benefits between MR and FPF. FPF was the preferred method for initial programming as selected by subject and clinician.
Conclusions:
FPF programming is a viable and efficient methodology that may be incorporated into clinical practice.
