Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recurrent myalgias associated with cimetidine.

M Labeeuw, J F Cabanne, P Dubot

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Toxicological effects of ambient fine (PM<sub>2.5-0.18</sub>) and ultrafine (PM<sub>0.18</sub>) particles in healthy and diseased 3D organo-typic mucocilary-phenotype models.

    Environmental research·2019
    Same author

    Imidazolium-based titanium substrates against bacterial colonization.

    Biomaterials science·2017
    Same author

    Effects of engineered iron nanoparticles on the bryophyte, Physcomitrella patens (Hedw.) Bruch & Schimp, after foliar exposure.

    Ecotoxicology and environmental safety·2015
    Same author

    [Flows between modalities in the treatment of ESRD].

    Nephrologie & therapeutique·2013
    Same author

    [Flows between treatment modalities of ESRD].

    Nephrologie & therapeutique·2012
    Same author

    Early recurrence of Type 2 diabetic nephropathy after kidney transplantation.

    Clinical nephrology·2011
    Same journal

    Distribution of lidocaine and digoxin in heart tissues and aorta following intrapericardial administration.

    International journal of clinical pharmacology, therapy, and toxicology·1993
    Same journal

    Population pharmacokinetic analysis of new aminoglycosides, astromicin and isepamicin, and evaluation of Bayesian prediction method for approximation of individual clearance of drug.

    International journal of clinical pharmacology, therapy, and toxicology·1993
    Same journal

    Comparison of the pharmacokinetics of 1,2-dimethyl-3-hydroxypyrid-4-one (L1) in healthy volunteers, with and without co-administration of ferrous sulfate, to thalassemia patients.

    International journal of clinical pharmacology, therapy, and toxicology·1993
    Same journal

    The effects of cimetidine, ranitidine and famotidine on the single-dose pharmacokinetics of naproxen and its metabolites in humans.

    International journal of clinical pharmacology, therapy, and toxicology·1993
    Same journal

    Is there a relationship between cytarabine pharmacokinetics and keratitis?--A case report.

    International journal of clinical pharmacology, therapy, and toxicology·1993
    Same journal

    Effect of DL-sodium lactate infusion on excretion of purine bases and oxypurinol.

    International journal of clinical pharmacology, therapy, and toxicology·1993
    See all related articles

    A hemodialysis patient developed recurrent myalgia (muscle pain) during cimetidine treatment. This suggests a potential progressive decrease in cimetidine tolerance with repeated exposure in susceptible individuals.

    Area of Science:

    • Pharmacology
    • Nephrology
    • Clinical Medicine

    Background:

    • Cimetidine is a histamine H2 receptor antagonist used to reduce stomach acid.
    • Hemodialysis patients may have altered drug metabolism and excretion.
    • Myalgia is a potential side effect of various medications.

    Observation:

    • A patient undergoing chronic hemodialysis reported recurrent myalgia during cimetidine (400 mg/day) therapy.
    • Myalgia episodes appeared progressively later in the course of repeated cimetidine treatments.
    • Pain resolved upon cimetidine withdrawal and recurred upon re-challenge, with no neurological signs or elevated CPK.

    Findings:

    • The patient experienced severe hip-predominant myalgia linked to cimetidine exposure.
    • Ranitidine treatment, another H2 antagonist, did not cause myalgia over four months.

    Related Experiment Videos

  • This case suggests a possible acquired intolerance or decreased tolerance to cimetidine with cumulative exposure.

    • Implications:

    • Clinicians should consider cimetidine-induced myalgia in hemodialysis patients with unexplained muscle pain.
    • The findings highlight the importance of monitoring for adverse effects, especially with repeated drug courses.
    • This case may indicate a need for careful consideration of cimetidine re-administration in susceptible patients.