Related Experiment Video
Updated: Jul 26, 2025
07:13
Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
Published on: February 13, 2021
2.3K
Integrated spatiotemporal transcriptomic resolution of embryonic palate osteogenesis
Jeremie Oliver Piña1,2,3, Resmi Raju1, Daniela M Roth1,4
1Section on Molecules & Therapies for Craniofacial & Dental Disorders, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.
Biorxiv : the Preprint Server for Biology
|June 19, 2023
Summary
This study maps gene expression during embryonic palate bone formation, identifying novel genes involved in palate fusion. This research provides a framework for understanding cleft palate anomalies.
Area of Science:
- Developmental Biology
- Molecular Biology
- Genetics
Background:
- Palate formation involves osteoblast differentiation and bone formation, separating oral and nasal cavities.
- Understanding the molecular mechanisms of palatal osteogenesis during fusion remains incomplete.
Conclusions:
- The study provides a comprehensive framework for understanding mammalian embryonic palatal osteogenesis.
- Identified novel genes offer candidate targets for investigating cleft palate anomalies.
- This research enhances our understanding of the molecular basis of palatal fusion.
