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Updated: Jul 26, 2025
11:47
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
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Zoledronic acid improves bone quality and muscle function in a high bone turnover state.
Biorxiv : the Preprint Server for Biology
|June 19, 2023
Summary
Zoledronic acid (ZA) improves bone health and muscle mass in mice with metabolic bone disease. This bisphosphonate treatment also enhances muscle function by regulating TGFβ release from bone.
Area of Science:
- Bone biology and skeletal muscle physiology
- Pharmacological interventions for metabolic bone disease
- Mechanisms of bone-muscle crosstalk
Background:
- Metabolic bone diseases are often associated with muscle weakness, impacting quality of life.
- The role of zoledronic acid (ZA) in muscle weakness unrelated to tumors is not well understood.
- Transforming growth factor beta (TGFβ) dysregulation in bone contributes to bone disorders and muscle weakness.
Conclusions:
- Zoledronic acid (ZA) demonstrates beneficial effects in maintaining bone health in a metabolic bone disease model.
- ZA treatment preserves muscle mass and function, suggesting its potential beyond bone health.
- Targeting TGFβ release from bone with ZA offers a therapeutic strategy for muscle weakness associated with bone disorders.
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