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Intestinal bacteria-a powerful weapon for fungal infections treatment

Liu Cong1, Chaoqun Chen1, Shanshan Mao1

  • 1School of Medical Technology, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Frontiers in Cellular and Infection Microbiology
|June 19, 2023
PubMed

Insights

Invasive fungal infections are increasing due to evolving fungal resistance. Intestinal bacteria offer novel strategies to combat these infections by targeting fungal virulence and boosting host immunity.

Area of Science:

  • Microbiology
  • Immunology
  • Drug Discovery

Background:

  • Invasive fungal infections (IFIs) pose a growing global health threat due to increasing fungal resistance.
  • The rise in IFIs necessitates novel therapeutic strategies beyond traditional antifungal drugs.
  • The gut microbiota, a complex ecosystem of microorganisms, plays a crucial role in host health and immunity.

Purpose of the Study:

  • To review the mechanisms by which intestinal bacteria can inhibit fungal growth and invasion.
  • To explore the potential of targeting fungal virulence factors and quorum sensing systems.
  • To highlight the role of bacterial metabolites and host immune modulation in combating fungal infections.

Main Methods:

  • Literature review of studies investigating the interactions between intestinal bacteria and pathogenic fungi.
  • Analysis of mechanisms including bacterial targeting of fungal virulence factors.
  • Examination of bacterial modulation of host immune responses against fungi.

Main Results:

  • Certain intestinal bacteria and probiotics demonstrate antifungal properties.
  • Mechanisms include inhibition of fungal growth, disruption of virulence factor production, and interference with fungal communication (quorum sensing).
  • Bacterial metabolites and modulation of host immunity are key factors in controlling fungal infections.

Conclusions:

  • Intestinal bacteria represent a promising source for developing new strategies against invasive fungal infections.
  • Targeting fungal virulence and leveraging the host-microbiota-immune axis offers a novel therapeutic avenue.
  • Further research into these interactions could lead to innovative treatments for challenging fungal diseases.
Keywords:
active metabolitesantifungalfungal resistanceprobioticstoxicity factor

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