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Increased structural connectivity in high schizotypy.

Eirini Messaritaki1, Sonya Foley1, Kali Barawi2

  • 1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.

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Summary
This summary is machine-generated.

This study found that higher schizotypy scores in healthy individuals correlate with altered structural brain connectivity in sensorimotor and default mode networks. These findings offer insights into the neural basis of schizotypy and potential links to schizophrenia.

Keywords:
Brain networksSchizophreniaSchizotypyStructural connectivityTractography

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Network Science

Background:

  • Schizotypy, a personality trait, shares etiological factors with schizophrenia.
  • Understanding the neural underpinnings of schizotypy may illuminate schizophrenia's pathophysiology.

Purpose of the Study:

  • To investigate the relationship between brain structural connectivity and schizotypy in healthy adults.
  • To explore graph theoretical properties of structural brain networks in relation to schizotypy scores.

Main Methods:

  • Utilized diffusion MRI data from two independent cohorts (140 and 115 participants) to construct structural brain networks.
  • Calculated graph theoretical metrics for default mode, sensorimotor, visual, and auditory subnetworks.
  • Correlated network metrics with schizotypy scores derived from the Schizotypal Personality Questionnaire (SPQ).

Main Results:

  • A positive correlation was observed between schizotypy scores and the mean node degree and mean clustering coefficient in sensorimotor and default mode subnetworks.
  • Key brain regions implicated include the right postcentral gyrus, left paracentral lobule, right superior frontal gyrus, left parahippocampal gyrus, and bilateral precuneus.
  • These identified nodes show compromised functional connectivity in schizophrenia.

Conclusions:

  • Structural brain network alterations are associated with schizotypy in healthy individuals.
  • Findings suggest that disruptions in sensorimotor and default mode networks may represent a shared neural vulnerability between schizotypy and schizophrenia.
  • This research provides novel insights into the neurobiological basis of schizotypy.