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Updated: Jul 26, 2025

Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
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Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

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A mechanistic pharmacokinetic model for intrathecal administration of antisense oligonucleotides

Andreas A Linninger1, Dipak Barua2, Yaming Hang2

  • 1University of Illinois at Chicago, Chicago, IL, United States.

Frontiers in Physiology
|June 19, 2023
PubMed

Keywords:
antisense oligodeonucleotidescentral nervous systemcomputational fluid dynamicsintrathecal deliverypharmacokinetic modeling and simulation

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