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Discrete Oligocarbamates Exhibit Sequence-Dependent Fluorescence Emission and Quenching
Emily A Hoff1,2, Richard K Weigel1, Adithya Rangamani1
1Robert Frederick Smith School of Chemical & Biomolecular Engineering, 120 Olin Hall, Cornell University, Ithaca, New York 14835, United States.
ACS Polymers Au
|June 19, 2023
Summary
Sequence-defined synthetic polymers, like vanillin-based oligocarbamates (SeDOCs), exhibit tunable material properties. Their sequence dictates dynamic fluorescence quenching, demonstrating a link between polymer structure and function from solution to solid state.
Area of Science:
- Polymer Chemistry
- Materials Science
- Biophysics
Background:
- Biological polymers achieve complex functions through precise monomer sequencing.
- Synthetic polymers can mimic this precision to create materials with tunable properties.
- Scalable synthesis of discrete macromolecules allows for studying sequence-dependent behavior.
Purpose of the Study:
- To investigate sequence-dependent properties in synthetic macromolecules.
- To demonstrate dynamic fluorescence quenching in sequence-defined oligocarbamates (SeDOCs).
- To link macromolecular conformation and fluorescence to polymer sequence.
Main Methods:
- Iterative solid- and solution-phase synthesis of vanillin-based monomers.
- Preparation of sequence-defined oligocarbamates (SeDOCs).
- Analysis of thermal, mechanical, and fluorescence properties in solution and solid phases.
Main Results:
- Scalable synthesis of isomeric SeDOCs with distinct thermal and mechanical properties.
- Observation of sequence-dependent dynamic fluorescence quenching in unimolecular SeDOCs.
- Fluorescence changes correlate with macromolecular conformation, which is sequence-driven.
Conclusions:
- Sequence-defined synthetic polymers offer a platform for creating materials with predictable and tunable properties.
- Dynamic fluorescence quenching is a sequence-dependent phenomenon in SeDOCs, applicable across different phases.
- Macromolecular conformation, dictated by sequence, is a key factor controlling fluorescence emission.
