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Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment
Li Zhou1, Xue Bai2, Jiagui Huang1
1Department of Neurology. The First Affiliated Hospital of Chongqing Medical University.
Nutricion Hospitalaria
|June 19, 2023
Summary
Vitamin B12 supplementation significantly improved neuropsychological function, particularly attention and calculation, in patients with cognitive impairment. This suggests vitamin B12 may enhance frontal lobe function in those experiencing cognitive decline.
Area of Science:
- Neurology
- Nutritional Neuroscience
Background:
- Cognitive impairment affects a significant portion of the middle-aged and elderly population.
- Neuropsychological deficits are a hallmark of cognitive decline.
- Vitamin B12 deficiency is increasingly recognized as a potential contributor to cognitive impairment.
Purpose of the Study:
- To investigate the efficacy of vitamin B12 supplementation in improving neuropsychological function.
- To assess the impact of vitamin B12 on disease progression in patients with cognitive impairment.
- To determine if vitamin B12 supplementation can enhance frontal lobe functions.
Main Methods:
- A prospective case-control study involving 115 participants with cognitive impairment.
- Randomized assignment into a vitamin B12 treatment group (n=58) and a control group (n=57).
- Neuropsychological assessments using MMSE and MoCA at baseline and after six months.
Main Results:
- Vitamin B12 treatment group showed significant improvements in attention and calculation (p < 0.01).
- Enhanced visual-constructional abilities were observed in the treatment group (p < 0.05).
- Overall improvement in neuropsychological function was noted compared to the control group.
Conclusions:
- Vitamin B12 supplementation shows promise in improving frontal lobe function in individuals with cognitive decline.
- Investigating vitamin B12 levels is crucial for all patients diagnosed with cognitive impairment.
- This study supports the role of vitamin B12 in maintaining cognitive health.
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