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Ulcerative colitis and thrombocytosis: Case report and literature review
Yaqi Zhou1, Fengqin Zhu2, Dehuai Jing2
1Department of Clinical Medicine, Jining Medical University, Jining, Shandong, P.R. China.
Rationale:
Ulcerative colitis (UC) is an autoimmune disease of unknown etiology, sometimes associated with anemia and thrombocytosis. Platelets (PLTs) play a role in amplifying inflammatory and immune responses in chronic inflammation. This study discusses the diagnosis and treatment of a case of UC combined with secondary thrombocytosis and reviews the relevant literature. We report an interaction between thrombocytosis and UC to raise clinicians' awareness of this condition.
Patient Concerns:
In the current report, we discuss the case of a 30-year-old female patient who presented with frequent diarrhea and thrombocytosis.
Diagnosis:
Severe UC combined with intestinal infection was diagnosed based on colonoscopy and intestinal biopsy. The patient had a PLT count >450 × 109/L and was diagnosed with reactive thrombocytosis.
Interventions And Outcomes:
The patient was discharged from the hospital in remission after receiving vedolizumab and anticoagulant treatment.
Lessons:
In patients with severe UC with thrombocytosis, clinicians should pay attention to PLTs promoting inflammatory progression, as well as screening for venous thromboembolism risk and prophylactic anti-venous thromboembolism therapy at the time of dosing to avoid adverse effects.
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