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Changes of intestinal flora in children with febrile seizure

Lin Yang1,2, Jianmei Tian2

  • 1The Second Affiliated Hospital of Shandong First Medical University, Tai'an, China.

Medicine
|June 19, 2023
PubMed

Insights

Febrile seizures in children are linked to differences in gut bacteria and metabolites. Restoring gut flora balance may help prevent and treat this neurological disorder.

Area of Science:

  • Microbiology
  • Metabolomics
  • Pediatric Neurology

Background:

  • Febrile seizure (FS) is a common childhood neurological disorder with unclear pathogenesis.
  • FS recurrence impacts child development and quality of life.

Purpose of the Study:

  • To investigate differences in intestinal flora and metabolomics between children with and without FS.
  • To explore the relationship between gut microbiota and metabolites in FS pathogenesis.

Main Methods:

  • 16S rDNA sequencing for gut microbiota analysis.
  • Liquid chromatography-mass spectrometry for fecal metabolomics.
  • Statistical analyses including LEfSe, OPLS-DA, and KEGG pathway analysis.

Main Results:

  • Significant differences in intestinal microbiome composition at the phylum level between FS and healthy children.
  • Identification of ten potential febrile seizure biomarkers, including xanthosine and taurine.
  • Three key metabolic pathways (taurine metabolism, glycine/serine/threonine metabolism, arginine biosynthesis) implicated in FS.
  • Correlation found between Bacteroides and specific differential metabolites.

Conclusions:

  • Gut microbiome alterations are associated with febrile seizures in children.
  • Specific metabolites and metabolic pathways may serve as FS markers.
  • Modulating intestinal flora balance offers a potential therapeutic strategy for FS.

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