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Updated: Jul 26, 2025

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Comprehensive Analysis of Transcription Dynamics from Brain Samples Following Behavioral Experience

Published on: August 26, 2014

Noncoding transcripts are linked to brain resting-state activity in non-human primates.

Wei Wang¹, Tingting Bo², Ge Zhang³

¹CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

|June 19, 2023

Summary

This summary is machine-generated.

Noncoding genes correlate with resting-state brain activity in macaques, similar to protein-coding genes. These noncoding genes link to brain cell function and neurological disorders like autism and schizophrenia.

Keywords:

CP: Neuroscience autism non-human primate noncoding RNA oligodendrocyte resting-state activity

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Published on: March 21, 2019

Area of Science:

Neuroscience
Genomics
Molecular Biology

Background:

Brain-derived transcriptomes correlate with human resting-state brain activity.
The association between transcriptomes and resting-state activity in nonhuman primates is not well understood.

Purpose of the Study:

To investigate molecular correlates of resting-state brain activity in macaque cortical regions.
To determine if noncoding genes contribute to variations in resting-state activity.

Main Methods:

Integration of 757 macaque transcriptomes from 100 cortical regions with resting-state activity data.
Analysis of noncoding gene expression and co-expression networks.
Comparison with human resting-state functional genes and disease-associated genes.

Main Results:

150 noncoding genes explained resting-state activity variations comparably to protein-coding genes.
Noncoding genes are linked to oligodendrocyte function and modules associated with autism and schizophrenia risk genes.
Genes linked to noncoding resting-state genes are enriched in human resting-state functional and memory-effect genes.
Altered links between noncoding genes and resting-state functional magnetic resonance imaging (fMRI) signals were observed in autistic brains.

Conclusions:

Noncoding genes, particularly noncoding RNAs, play a significant role in explaining resting-state brain activity in nonhuman primates.
These findings suggest potential noncoding RNA involvement in neurological disorders and cognitive functions.