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An update on novel therapies for treating patients with arterial thrombosis

Udaya S Tantry1, Sanchit Duhan1, Eliano Navarese2

  • 1Sinai Center for Thrombosis Research, Sinai Hospital of Baltimore, Baltimore, MD, USA.

Expert Review of Hematology
|June 19, 2023
PubMed
Abstract

Insights

New antithrombotic therapies are being developed to address unmet needs in arterial diseases. Research focuses on novel antiplatelet agents and inhibitors targeting collagen and thrombin pathways to improve treatment efficacy and reduce bleeding risks.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Antithrombotic therapy is rapidly evolving, with new strategies targeting existing and novel pathways for arterial diseases.
  • Current antiplatelet agents have limitations, including a ceiling effect and increased bleeding risk, highlighting unmet needs.

Purpose of the Study:

  • To provide a comprehensive review of emerging antithrombotic agents for arterial diseases.
  • To discuss advancements in upstream antiplatelet agents and inhibitors of collagen and thrombin pathways.

Main Methods:

  • Literature search of PubMed for English language articles.
  • Keywords included: antiplatelet agents, thrombin pathway inhibitors, collagen receptors, arterial disease.

Main Results:

  • Exploration of new targets like collagen receptors and thrombin generation (FXa, FXIa, FXIIa) is ongoing.
  • Novel antiplatelet agents and strategies are being investigated for upstream therapy in high-risk patients.

Conclusions:

  • Despite progress, significant unmet needs persist in treating arterial diseases with antithrombotics.
  • New targets and agents aim to enhance efficacy while minimizing bleeding complications.
Keywords:
FXAFXIIaFXIaGPIIb/IIIa receptorGPVI receptorP2Y12 receptoracetyl salicylic acidantithrombotic agentsarterial thrombosis

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