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Updated: Jul 26, 2025

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
Early-Stage Triple-Negative Breast Cancer Journey: Beginning, End, and Everything in Between
Hyo Sook Han1, Praveen Vikas2, Ricardo L B Costa1
1Department of Breast Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Abstract:
Triple-negative breast cancer (TNBC) is a very heterogeneous and aggressive breast cancer subtype with a high risk of mortality, even if diagnosed early. The mainstay of early-stage breast cancer includes systemic chemotherapy and surgery, with or without radiation therapy. More recently, immunotherapy is approved to treat TNBC, but managing immune-rated adverse events while balancing efficacy is a challenge. The purpose of this review is to highlight the current treatment recommendations for early-stage TNBC and the management of immunotherapy toxicities.
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