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Knowledge Gaps in Placenta Accreta Spectrum.

Daniela A Carusi¹, Christina M Duzyj², Jonathan L Hecht³

¹Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

American Journal of Perinatology

|June 19, 2023

Summary

This summary is machine-generated.

Research on placenta accreta spectrum disorders can advance with standardized terminology and large databases. Future studies should explore prediction beyond ultrasound and focus on prevention and long-term patient support.

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Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine

Background:

Placenta accreta and its variants have evolved significantly in incidence, risk factors, presentation, diagnosis, and management since the early 20th century.
Despite improvements from diagnostic tools and multidisciplinary care, understanding of pathophysiology, epidemiology, and optimal management remains limited.

Purpose of the Study:

To highlight the need for standardized terminology and large databases to accelerate research in placenta accreta spectrum disorders.
To advocate for expanded research into non-traditional phenotypes, improved prediction methods, and long-term patient support.

Main Methods:

Review of historical and current understanding of placenta accreta spectrum disorders.
Analysis of trends in incidence, risk factors, and clinical presentation.
Discussion of current diagnostic and management strategies.

Main Results:

Placenta accreta spectrum research can be enhanced by standardized terminology and the use of large databases.
Prediction of placenta accreta should incorporate biomarkers beyond ultrasound and consider patients without traditional risk factors.
Future research should aim to identify preventive strategies for accreta development.

Conclusions:

Standardized terminology and large databases are crucial for advancing placenta accreta spectrum research.
Future research must broaden diagnostic approaches, investigate preventive measures, and address the long-term needs of affected patients.