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Updated: Jul 26, 2025
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Isolation of Murine Spermatogenic Cells using a Violet-Excited Cell-Permeable DNA Binding Dye
Published on: January 14, 2021
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The molecular evolution of mammalian spermatogenesis
Nils Trost1, Noe Mbengue1, Henrik Kaessmann1
1Center for Molecular Biology (ZMBH), DKFZ-ZMBH Alliance, Heidelberg University, Heidelberg, Germany.
Cells & Development
|June 19, 2023
Summary
Male reproductive organ evolution is rapid, driven by evolutionary pressures. Transcriptomic studies reveal molecular mechanisms and gene programs underlying testis evolution and male fertility.
Area of Science:
- Reproductive Biology
- Evolutionary Biology
- Genomics
Background:
- The testis is crucial for male reproduction, producing gametes via spermatogenesis.
- Mammalian testis morphology, sperm traits, and spermatogenesis evolve rapidly.
- Evolutionary pressures on males likely drive this rapid evolution.
Conclusions:
- Molecular evolution studies provide deep insights into testis function and evolution.
- Accumulated data serve as a resource for understanding and treating male infertility.
- Rapid evolution of the testis is linked to reproductive success and fertility challenges.
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