The Role of the Corpus Callosum (Micro)Structure in Bimanual Coordination: A Literature Review Update

The characterization of callosal white matter is crucial for understanding the relationship between brain structure and bimanual motor function. An earlier literature review established this. With advancements in neuroimaging and data modeling, we aim to provide an update on the existing literature. Firstly, we highlight new CC parcellation approaches, such as functional MRI- and atlas-informed tractography and in vivo histology. Secondly, we elaborate on recent insights into the CC's role in bimanual coordination, drawing evidence from studies on healthy young and older adults, patients and training-related callosal plasticity. We also reflect on progress in the field and propose future perspectives to inspire research on the underlying mechanisms of structural-functional interactions.