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Cell and circuit complexity of the external globus pallidus
Connor D Courtney1, Arin Pamukcu1, C Savio Chan2
1Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Nature Neuroscience
|June 19, 2023
Summary
The external globus pallidus (GPe) is more complex than previously thought, with diverse cell types and circuits. Recent research reveals its involvement in both direct and indirect basal ganglia pathways and non-motor functions.
Area of Science:
- Neuroscience
- Cell Biology
- Systems Neuroscience
Background:
- The external globus pallidus (GPe) was traditionally viewed as a homogeneous relay station in the basal ganglia's indirect pathway.
- Limited understanding of GPe cell types and circuits hindered research.
Purpose of the Study:
- To review recent findings on the cellular and circuit complexity of the GPe.
- To challenge traditional views of the basal ganglia based on new GPe data.
Main Methods:
- Review of recent experimental data from rodent models.
- Analysis of afferent and efferent connections of the GPe.
- Exploration of GPe's role in motor and non-motor functions.
Main Results:
- The GPe comprises a complex network of diverse neuron populations and circuits.
- GPe connections are involved in both direct and indirect basal ganglia pathways.
- The GPe exhibits extensive connectivity beyond the basal ganglia, suggesting multifaceted roles.
Conclusions:
- The GPe's complexity challenges established models of basal ganglia function.
- Emerging data support novel computational rules for the basal ganglia, incorporating the GPe's broader influence.
- The GPe plays significant roles in both motor and non-motor functions.
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