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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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The crisscross between p53 and metabolism in cancer

Youxiang Mao1,2, Peng Jiang1,2

  • 1State Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Acta Biochimica Et Biophysica Sinica
|June 20, 2023
PubMed

Insights

The tumor suppressor p53 (p53) regulates metabolism in cancer. Metabolites influence p53 activity, and mutant p53 proteins exhibit distinct metabolic roles compared to wild-type p53.

Area of Science:

  • Oncology
  • Molecular Biology
  • Metabolic Regulation

Background:

  • The p53 protein is a critical tumor suppressor involved in cell cycle control, DNA repair, and apoptosis.
  • Mutations in the p53 gene are frequent in human cancers, yet the mechanisms driving tumorigenesis remain unclear.
  • Emerging research highlights p53's significant role in regulating cellular metabolism and adaptation to nutrient deprivation.

Approach:

  • This review summarizes current knowledge on p53's role in anabolic and catabolic metabolism within cancer.
  • It specifically examines recent discoveries regarding metabolite-mediated regulation of p53 functions.
  • The review also contrasts the metabolic regulatory functions of wild-type p53 with those of mutant p53 variants.

Key Points:

  • Wild-type p53 (p53) mediates both anabolic and catabolic metabolic processes crucial for cancer cells.
  • Metabolites can directly influence the activity and function of p53.
  • Mutant p53 proteins, particularly missense mutants, display altered and often opposing metabolic functions compared to wild-type p53.

Conclusions:

  • p53 is a key regulator of cancer metabolism, influencing diverse metabolic pathways.
  • Metabolite-p53 interactions represent a complex regulatory network with implications for tumor development.
  • Understanding the differential roles of wild-type and mutant p53 in metabolism is essential for developing targeted cancer therapies.
Keywords:
cancergene regulationmetabolic reprogrammingmetabolite sensingp53

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