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Updated: Jul 26, 2025

Isolation, Characterization, and Therapeutic Application of Extracellular Vesicles from Cultured Human Mesenchymal Stem Cells
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Mesenchymal Stem Cells-Derived Apoptotic Extracellular Vesicles (ApoEVs): Mechanism and Application in Tissue

Yufan Zhu1, Xihang Chen1, Yunjun Liao1

  • 1Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

Stem Cells (Dayton, Ohio)
|June 20, 2023
PubMed

Insights

Mesenchymal stem cell-derived apoptotic extracellular vesicles (MSCs-ApoEVs) show promise for tissue regeneration. These vesicles, released during cell death, mediate intercellular communication and promote healing across various tissues.

Area of Science:

  • Cellular Biology
  • Regenerative Medicine
  • Biotechnology

Background:

  • Mesenchymal stem cells (MSCs) are vital for cellular therapy due to their immunosuppressive and regenerative properties.
  • MSCs experience significant apoptosis post-transplantation, releasing apoptotic extracellular vesicles (MSCs-ApoEVs).
  • MSCs-ApoEVs are potent intercellular communicators, rich in bioactive molecules like miRNomes, metabolites, and proteomes.

Conclusions:

  • MSCs-ApoEVs represent a promising cell-free therapeutic approach for tissue regeneration.
  • Understanding their mechanisms and optimizing their application are key for clinical translation.
  • Further research into MSCs-ApoEVs can unlock new regenerative medicine strategies.
Keywords:
apoptotic extracellular vesiclesdrug delivery platformmesenchymal stem cellstissue regeneration

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