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Porcine Corneal Tissue Explant to Study the Efficacy of Herpes Simplex Virus-1 Antivirals
Published on: September 20, 2021
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Herpes simplex virus type 1 in periapical pathoses: Systematic review and meta-analysis
Paolo G Arduino1, Mario Alovisi1, Stefano Petti2
1Department of Surgical Science, CIR-Dental School, University of Turin, Turin, Italy.
Oral Diseases
|June 20, 2023
Summary
Herpes simplex virus type 1 (HSV-1) may infect 3%-11% of periapical lesions, though its causative role in disease is not confirmed. Further research is needed to understand HSV-1
Area of Science:
- Endodontics
- Oral microbiology
- Infectious diseases
Background:
- Periapical lesions are inflammatory responses to pulpal infection.
- The role of specific viruses, like herpes simplex virus type 1 (HSV-1), in these lesions is debated.
Purpose of the Study:
- To systematically review and meta-analyze observational studies.
- To assess the prevalence of HSV-1 infection in endodontic periapical lesions.
Main Methods:
- Searched multiple databases (MEDLINE, Scopus, Embase, Web of Science, Google Scholar).
- Included cross-sectional studies on HSV-1 in periapical tissues.
- Utilized fixed-effect and random-effects models for meta-analysis, with adjustments for quality and bias.
Main Results:
- Eight studies involving 194 patients were included.
- Pooled HSV-1 prevalence in periapical lesions ranged from 3% to 11% across different analytical models.
- Prevalence estimates were adjusted for study quality and potential publication bias.
Conclusions:
- HSV-1 can colonize periapical tissues in a notable percentage of patients with periapical diseases.
- Current data do not establish a causal link between HSV-1 and the development or progression of periapical diseases.
- High-quality, large-scale prospective cohort studies are recommended for future research.
