Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Considerations for the selection and phenotyping of mouse models for the study of Alzheimer's disease.

STAR protocols·2026

Same author

First report of Q fever endocarditis in Taiwan.

Journal of the Formosan Medical Association = Taiwan yi zhi·2026

Same author

Using structured video review guidance to surface interprofessional participation patterns during ward rounds.

Medical education·2026

Same author

Development and validation of the clinical educator self-regulated learning scale (CTSRS): insights from faculty development.

BMC medical education·2025

Same author

Clinical Characteristics and Angioplasty Outcomes in Lower Extremity Artery Disease Patients with Normal Ankle-Brachial Index: A Clinical Conundrum.

Acta Cardiologica Sinica·2025

Same author

Role of health information technology in enhancing chronic disease management: a scoping review protocol.

BMJ open·2025

Search research articles

Related Experiment Video

Updated: Jul 26, 2025

Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats

Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats

Published on: June 18, 2018

Cognitive rescue in aging through prior training in rats.

Alexandra Gros¹, Szu-Han Wang¹

¹Centre for Clinical Brain Sciences, The University of Edinburgh, Chancellor’s Building, Edinburgh, Scotland, UK.

|June 20, 2023

Summary

Aging impairs long-term memory, but short-term memory persists. Prior training in rats improved cognitive function and long-term memory, offering insights into aging and memory enhancement.

Keywords:

cognitive stimulation lifelong training memory consolidation memory modulation reconsolidation

More Related Videos

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

Published on: April 15, 2014

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

Related Experiment Videos

Last Updated: Jul 26, 2025

Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats

Testing for Metacognitive Responding Using an Odor-based Delayed Match-to-Sample Test in Rats

Published on: June 18, 2018

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

A Fully Automated Rodent Conditioning Protocol for Sensorimotor Integration and Cognitive Control Experiments

Published on: April 15, 2014

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Gathering Self-Initiated Rat Behavioral Data to Characterize Post-Stroke Deficits

Published on: March 15, 2024

Area of Science:

Neuroscience
Cognitive Psychology
Aging Research

Background:

Cognitive decline, particularly in spatial memory, is a hallmark of aging.
Understanding memory persistence mechanisms is crucial for developing interventions to improve cognitive health in older adults.
Behavioral tagging, where novel events enhance memory consolidation, offers a potential avenue for memory enhancement.

Purpose of the Study:

To investigate the effects of aging on different memory processes, specifically encoding, consolidation, and maintenance.
To determine if prior training experiences can mitigate age-related cognitive decline in spatial memory.
To explore the role of novelty during memory reactivation and reconsolidation in maintaining memories during aging.

Main Methods:

Two groups of aged rats were trained on an appetitive delayed matching-to-place task.
One group received prior training in young and mid-life stages, creating a longitudinal design.
Memory performance was assessed, focusing on short-term, intermediate, and long-term memory components.

Main Results:

Aged rats without prior training exhibited significant long-term memory decline, suggesting impaired encoding and consolidation.
Short-term memory remained intact in aging.
Introducing novelty during memory reactivation and reconsolidation successfully maintained memories in aged rats.
Prior training enhanced cognitive performance, strengthened short-term and intermediate memory, and facilitated encoding-boosted long-term memory.

Conclusions:

Aging selectively affects long-term memory processes like encoding and consolidation, while short-term memory is more resilient.
Behavioral tagging principles, involving novelty, can be leveraged to maintain memories during aging.
Early-life and mid-life training experiences confer lasting cognitive benefits, improving performance and memory capacity in late aging.