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Association between serum total cholesterol and chronic kidney disease progression in children: results from the

Hee Sun Baek1, Min Ji Park2, Ji Yeon Song3

  • 1Department of Pediatrics, Yeungnam University, College of Medicine, Daegu, South Korea.

Pediatric Nephrology (Berlin, Germany)
|June 20, 2023
PubMed

Insights

Very high serum total cholesterol significantly accelerates chronic kidney disease (CKD) progression in children. Managing cholesterol levels is crucial for delaying CKD advancement in pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Risk Factors
  • Chronic Kidney Disease (CKD) Progression

Background:

  • Dyslipidemia is a significant risk factor for cardiovascular disease and mortality in pediatric chronic kidney disease (CKD).
  • Early detection and management of dyslipidemia are critical for improving outcomes in children with CKD.

Purpose of the Study:

  • To investigate the association between serum total cholesterol levels and the progression of CKD in children.
  • To determine if elevated cholesterol impacts the rate of CKD advancement over time.

Main Methods:

  • Analysis of data from 379 children in the KoreaN cohort study for Outcomes in patients With Pediatric CKD (KNOW-PedCKD).
  • Participants were categorized into four groups based on serum total cholesterol levels.
  • Survival analysis using time-dependent Cox proportional hazards models was employed to assess CKD progression events.

Main Results:

  • The incidence of CKD progression was highest in the 'very high' total cholesterol category (≥240 mg/dL) at 270.6 cases per 1000 person-years.
  • Children with very high cholesterol had a significantly higher hazard ratio for CKD progression (3.13 univariate, 2.37 multivariate) compared to those with acceptable levels (<170 mg/dL).

Conclusions:

  • Elevated serum total cholesterol is a significant predictor of CKD progression in pediatric populations.
  • Maintaining serum total cholesterol below the 'very high' threshold may be a key strategy to slow CKD progression in children.
Abstract

Keywords:
CKD progressionCardiovascular diseaseChildrenChronic kidney diseaseDyslipidemiaTotal cholesterol

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