Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

Disorders of the Nervous Tissue

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

Myasthenia Gravis: Overview and Treatment

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...

Chemical Synapses

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...

Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Symptoms of respiratory illness in wind players and their relationship to instrument hygiene.

Scientific reports·2026

Same author

Resilience Mitigates the Link between Adverse Childhood Experiences and Musician's Dystonia: A Neuroendocrine and Psychological Perspective.

Tremor and other hyperkinetic movements (New York, N.Y.)·2026

Same author

Music Ensemble: a large dataset on musicianship, cognition, and personality in musicians and nonmusicians.

Scientific data·2026

Same author

Divergent Recovery Paths in Musicians' Dystonia.

Tremor and other hyperkinetic movements (New York, N.Y.)·2026

Same author

Quantification of Loudness Instability in Tone Production in Embouchure Dystonia.

Journal of movement disorders·2025

Same author

The Diverse Neuromuscular Spectrum of VPS13A Disease.

Annals of clinical and translational neurology·2025

Search research articles

Related Experiment Video

Updated: Jul 26, 2025

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia

Published on: September 12, 2020

Embouchure Dystonia as a Network Disease.

Johanna Doll-Lee¹, André Lee^2,3, Tobias Mantel⁴

¹Department of Neurology, Hannover Medical School, Hannover, Germany. doll-lee.johanna@mh-hannover.de.

Advances in Neurobiology

|June 20, 2023

Summary

Embouchure dystonia involves brain network alterations, including sensorimotor and inhibitory deficits. This study proposes a novel network model for musician's dystonia based on recent findings.

Keywords:

Embouchure dystonia Movement disorder Musician’s dystonia Network disorder Task specificity

More Related Videos

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Published on: January 27, 2018

Related Experiment Videos

Last Updated: Jul 26, 2025

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia

Implantation of Osmotic Pumps and Induction of Stress to Establish a Symptomatic, Pharmacological Mouse Model for DYT/PARK-ATP1A3 Dystonia

Published on: September 12, 2020

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

A Protocol for Comprehensive Assessment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis ALS

Published on: February 21, 2011

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Published on: January 27, 2018

Area of Science:

Neuroscience
Movement Disorders
Musician Health

Background:

Embouchure dystonia, a focal dystonia in musicians, has unclear pathophysiology.
Existing research suggests altered brain function and networks contribute to this condition.
Deficits in sensorimotor integration, sensory processing, and inhibition are implicated.

Purpose of the Study:

To propose a novel network model for embouchure dystonia.
To synthesize current electrophysiological and neuroimaging findings.
To advance understanding of the neural basis of musician's dystonia.

Main Methods:

Review of electrophysiological studies.
Analysis of recent neuroimaging research.
Development of a network model based on integrated data.

Main Results:

Embouchure dystonia is characterized by maladaptive plasticity.
Deficient inhibitory mechanisms are evident at multiple neural levels.
The basal ganglia and cerebellum are functionally involved, indicating a network disorder.

Conclusions:

Embouchure dystonia is best understood as a network disorder.
A novel network model integrates current pathophysiological insights.
Further research can refine this model for therapeutic targets.