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The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Experimental Study of Antidepressant Properties of Afobazole
I G Kapitsa1, A A Alymov2, E V Savinkova2
1V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. ingakap73@mail.ru.
Abstract:
We studied the effects of oral administration of Afobazole in a dose of 10 mg/kg for 5 days on depressive-like behavior of male C57BL/6 mice in the tail suspension test in comparison with amitriptyline (10 mg/kg) or fluoxetine (20 mg/kg) treatment. Afobazole produced an antidepressant effect similar to amitriptyline, but inferior to fluoxetine. The σ1 receptor antagonist BD-1047 in a dose of 5 mg/kg blocked the antidepressant effect of Afobazole, which indicates the involvement of σ1 receptors in the antidepressant effect of the drug.
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