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Selenium Biomarkers and Their Relationship to Cardiovascular Risk Parameters in Obese Women
Bruna Emanuele Pereira Cardoso1, Tamires da Cunha Soares2, Thaline Milany da Silva Dias2
1Department of Nutrition, Federal University of Piaui, Teresina, Brazil. brunaemanuelec@hotmail.com.
Biological Trace Element Research
|June 20, 2023
Summary
Obese women have lower selenium intake and higher urinary selenium levels, alongside increased cardiovascular risk factors. Selenium may play a protective role against cardiovascular disease in obesity.
Area of Science:
- Nutritional Biochemistry
- Cardiovascular Health
- Human Physiology
Background:
- Obesity is a global health concern associated with increased cardiovascular disease (CVD) risk.
- Selenium is an essential trace element with antioxidant properties, potentially influencing metabolic and cardiovascular health.
- Nutritional status of selenium and its relationship with obesity and CVD risk factors require further investigation.
Purpose of the Study:
- To investigate the association between selenium status (dietary intake, plasma, erythrocyte, and urinary concentrations) and cardiovascular risk parameters in obese women compared to eutrophic women.
- To explore correlations between selenium levels and various anthropometric and biochemical markers of cardiovascular risk.
Main Methods:
- Cross-sectional study involving 210 women (84 obese, 126 eutrophic).
- Measurements included anthropometrics (weight, height, WC, hip/neck circumference), lipid profiles, blood pressure, and selenium levels in plasma, erythrocytes, and urine.
- Calculated waist-hip ratio, conicity index, and Castelli indices.
Main Results:
- Obese women exhibited significantly lower mean dietary selenium intake and plasma/erythrocyte selenium concentrations, but higher urinary selenium concentrations compared to eutrophic women.
- Obese women showed elevated cardiovascular risk parameters including waist circumference, neck circumference, waist-hip ratio, conicity index, triacylglycerols (TGC), and VLDL-c.
- Negative correlations were observed between plasma selenium and total cholesterol, non-HDL, LDL-c, and SBP. Dietary selenium negatively correlated with several CVD risk markers and positively with HDL-c and DBP.
Conclusions:
- Women with obesity present altered selenium nutritional status and heightened cardiovascular risk.
- Findings suggest a potential protective role of selenium in mitigating cardiovascular disease risk in the context of obesity.
- Further research, including intervention studies, is warranted to confirm selenium's role in CVD prevention among obese individuals.
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