Related Experiment Video
Updated: Jul 26, 2025

Author Spotlight: A Non-Intubated Video-Assisted Thoracoscopic Surgery with Multimodal Analgesia and Sevoflurane Inhalation Anesthesia
Published on: May 26, 2023
Total intravenous anesthesia versus inhalation anesthesia: how do outcomes compare?
1Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Propofol-based total intravenous anesthesia (TIVA) offers benefits for specific surgical scenarios, particularly in reducing postoperative nausea and vomiting. However, its use is limited by perceived risks and a lack of evidence in some clinical situations.
Area of Science:
- Anesthesiology
- Surgical Care
Background:
- General anesthesia employs volatile anesthetics or propofol-based total intravenous anesthesia (TIVA).
- Despite proven safety, propofol-based TIVA utilization is low.
- Perceived risks, device limitations, and clinician preference contribute to low TIVA use.
Approach:
- This review synthesizes clinical evidence comparing propofol-based TIVA and volatile anesthetics.
- Outcomes examined include postoperative nausea and vomiting, pain, recovery quality, cognitive dysfunction, and cancer outcomes.
Key Points:
- Propofol-based TIVA may benefit patients experiencing postoperative nausea and vomiting.
- Evidence supporting propofol-based TIVA in certain clinical scenarios remains limited.
- The strength of evidence for propofol-based TIVA varies across different postoperative outcomes.
Conclusions:
- Propofol-based TIVA presents advantages in specific postoperative scenarios.
- Clinical application of propofol-based TIVA is debated due to inconsistent evidence.
- Further research is needed to clarify the role of propofol-based TIVA in diverse surgical contexts.
Related Concept Videos
Inhalational Anesthetics: Overview
Parenteral Anesthetics: Overview
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Stages of General Anesthesia
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...

