Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Function Tests01:25

Pulmonary Function Tests

382
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
382
Respiratory Volumes01:15

Respiratory Volumes

1.6K
Respiratory volumes are crucial metrics, meticulously measured to quantify the air exchanged in and out of the lungs during various phases of the breathing cycle. These precise measurements are vital for assessing lung function, diagnosing respiratory conditions, and monitoring overall respiratory health. Each parameter provides specific insights into the mechanics of breathing and the functional capacity of the lungs.
Tidal Volume (TV) Tidal volume (TV) is the air inhaled or exhaled in a...
1.6K
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

1.5K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
1.5K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

255
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
255
Assessment of Ventilation I: Respiratory Rate01:20

Assessment of Ventilation I: Respiratory Rate

1.2K
Assessment of Ventilation
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mental Well-Being Is Associated With Temporomandibular Disorder Pain Onset and Remission.

Journal of oral rehabilitation·2026
Same author

Left ventricular mechanical dispersion in a middle-aged population: associations with subclinical cardiac remodelling and cardiovascular risk.

Open heart·2026
Same author

Dampness and mould over 20 years and new onset of respiratory symptoms, asthma and rhinitis.

Journal of hazardous materials·2026
Same author

Developing low-carbon salbutamol MDI: assessment of relative bioavailability and pharmacodynamic relative potency of salbutamol MDI with propellant HFA-152a.

BMJ open respiratory research·2026
Same author

Comparison of airway mucin 5AC and 5B expression in preterm-born adults and asthma.

ERJ open research·2026
Same author

Diastolic dysfunction is equally common in pre-diabetes and diabetes and associated with concomitant cardiometabolic risk factors.

Open heart·2026
Same journal

Association Between Air Pollution and Post Acute Sequelae of SARS-CoV-2 (PASC).

American journal of respiratory and critical care medicine·2026
Same journal

When an Exacerbation Signals a Different Future in non-severe asthma.

American journal of respiratory and critical care medicine·2026
Same journal

Aim High-Stay Stable: Rethinking Treatment Success in COPD.

American journal of respiratory and critical care medicine·2026
Same journal

Three versus six weeks of corticosteroids for mild immune-related pneumonitis: a randomized trial.

American journal of respiratory and critical care medicine·2026
Same journal

Signal in the Noise: Polygenic Scores and the Problem of Defining Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine·2026
Same journal

Do mtDNA fragmentomic peaks reflect cancer biology or preanalytical and technical artifacts in NSCLC?

American journal of respiratory and critical care medicine·2026
See all related articles

Related Experiment Video

Updated: Jul 26, 2025

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.6K

Consequences of Using Post- or Prebronchodilator Reference Values in Interpreting Spirometry.

Andrei Malinovschi1, Xingwu Zhou1,2,3, Anders Andersson4,5

  • 1Department of Medical Sciences, Clinical Physiology.

American Journal of Respiratory and Critical Care Medicine
|June 20, 2023
PubMed
Summary
This summary is machine-generated.

Using postbronchodilator reference values for spirometry significantly increases the detection of airflow obstruction, revealing a higher respiratory burden in the general population. This approach may help identify individuals with milder chronic obstructive pulmonary disease symptoms.

Keywords:
post-bronchodilatorpre-bronchodilatorreference valuesrespiratory burdenspirometry

More Related Videos

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

9.4K
Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

7.2K

Related Experiment Videos

Last Updated: Jul 26, 2025

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.6K
Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship
08:25

Combining Volumetric Capnography And Barometric Plethysmography To Measure The Lung Structure-function Relationship

Published on: January 8, 2019

9.4K
Conducting Respiratory Oscillometry in an Outpatient Setting
14:49

Conducting Respiratory Oscillometry in an Outpatient Setting

Published on: April 8, 2022

7.2K

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology
  • Epidemiology

Background:

  • Postbronchodilator spirometry is standard for diagnosing chronic obstructive pulmonary disease (COPD).
  • Current interpretation often uses prebronchodilator reference values, potentially underestimating obstruction prevalence.
  • The SCAPIS study provides a unique dataset to investigate this discrepancy.

Purpose of the Study:

  • To compare spirometry prevalence rates using pre- vs. postbronchodilator reference values.
  • To assess the clinical impact of using different reference values on identifying respiratory burden.
  • To evaluate the interpretation of postbronchodilator spirometry in a general population.

Main Methods:

  • Utilized reference values from the SCAPIS study (10,156 healthy non-smokers for postbronchodilator, 1,498 for prebronchodilator).
  • Analyzed spirometry data from 28,851 individuals in the SCAPIS general population.
  • Compared FEV1/FVC ratios against both pre- and postbronchodilator lower limits of normal (LLN).

Main Results:

  • Bronchodilation shifted predicted medians higher and LLNs lower for FEV1/FVC.
  • Prevalence of airflow obstruction (postbronchodilator FEV1/FVC < postbronchodilator LLN) was 9.9%.
  • An additional 5.1% identified using prebronchodilator LLNs showed increased respiratory symptoms, emphysema, and self-reported COPD.

Conclusions:

  • Significant differences exist between pre- and postbronchodilator spirometry reference values for FEV1/FVC.
  • Employing postbronchodilator reference values doubled the detected prevalence of airflow obstruction.
  • This method may enhance early identification of mild COPD and improve clinical relevance.