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A validated prognostic nomogram for patients with H3 K27M-mutant diffuse midline glioma
Youheng Peng1, Yanming Ren1, Bowen Huang1
1Department of Neurosurgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan, People's Republic of China.
Scientific Reports
|June 20, 2023
Summary
This study identified key factors like age and KPS score to predict survival in diffuse midline glioma patients. A validated model aids in forecasting prognosis for H3 K27M-mutant diffuse midline glioma (H3 K27M-mt DMG).
Area of Science:
- Neuro-oncology
- Cancer Prognostics
- Molecular Pathology
Background:
- H3 K27M-mutant diffuse midline glioma (H3 K27M-mt DMG) is an aggressive brain tumor with limited prognostic understanding.
- Existing prognostic factors for H3 K27M-mt DMG are not fully defined, and no clinical prediction model is available.
Purpose of the Study:
- To develop and validate a prognostic model for predicting survival probability in patients with H3 K27M-mt DMG.
- To identify significant prognostic factors influencing survival in this patient population.
Main Methods:
- Utilized Cox proportional hazard regression for survival analysis on a training cohort (n=105) and an external validation cohort (n=43).
- Adjusted for known prognostic factors and incorporated age, preoperative KPS score, radiotherapy, and Ki-67 expression level into the model.
Main Results:
- The prognostic model identified age, preoperative KPS score, radiotherapy, and Ki-67 expression as significant factors influencing survival.
- Internal validation showed strong consistency indices (0.776 at 6 months), and external validation demonstrated good discrimination (0.785) and calibration.
Conclusions:
- A validated prognostic model has been established for H3 K27M-mt DMG, incorporating key clinical and molecular factors.
- This model can assist clinicians in predicting survival probability and managing patients with H3 K27M-mutant diffuse midline glioma.
