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Abnormal cerebral blood flow and brain function in type 2 diabetes mellitus
Mingrui Li1,2,3, Yifan Li1,2, Kui Zhao1,2
1First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Endocrine
|June 20, 2023
Summary
Type 2 diabetes mellitus (T2DM) is linked to reduced cerebral blood flow and altered brain activity. This study suggests these changes may be a compensatory mechanism for neural activity in T2DM patients.
Area of Science:
- Neuroscience
- Radiology
- Endocrinology
Background:
- Type 2 diabetes mellitus (T2DM) is associated with impaired cerebral blood perfusion, potentially affecting cognitive function.
- Understanding the neurobiological underpinnings of T2DM is crucial for developing targeted interventions.
Purpose of the Study:
- To evaluate the impact of T2DM on cerebral blood flow (CBF) and explore alterations in functional connectivity (FC).
- To investigate changes in spontaneous brain activity using amplitude of low-frequency fluctuation (ALFF) and degree centrality (DC).
Main Methods:
- Recruited 40 T2DM patients and 55 healthy controls (HCs).
- Utilized 3D-T1WI, resting-state functional MRI (rs-fMRI), and arterial spin labeling (ASL) scans.
- Administered cognitive tests and analyzed relationships between clinical, cognitive, and imaging data.
Main Results:
- T2DM patients exhibited lower CBF in the Calcarine_L and Precuneus_R regions compared to HCs.
- Elevated DC in Paracentral_Lobule_L and Precuneus_L, and higher ALFF in Hippocampus_L were observed in T2DM patients.
- Lower CBF in Calcarine_L correlated negatively with fasting insulin and HOMA_IR.
Conclusions:
- T2DM is associated with cerebral hypoperfusion linked to insulin resistance.
- Abnormally elevated brain activity and enhanced functional connectivity in T2DM may represent a compensatory mechanism.
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