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Aromatization by skeletal muscle.

H Matsumine, K Hirato, T Yanaihara

    The Journal of Clinical Endocrinology and Metabolism
    |September 1, 1986
    PubMed
    Summary
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    Muscle tissue in men and postmenopausal women exhibits aromatase activity, producing estrogen. This finding suggests muscle, like fat, is a significant extragonadal source of circulating estrogens.

    Area of Science:

    • Endocrinology
    • Metabolism
    • Human Physiology

    Background:

    • Peripheral aromatization is the primary source of circulating estrogens in men and postmenopausal women.
    • Aromatase enzyme converts androgens to estrogens.
    • The role of muscle tissue in extraglandular estrogen production remains largely uncharacterized.

    Purpose of the Study:

    • To investigate aromatase activity in skeletal muscle homogenates from men and postmenopausal women.
    • To quantify estrogen production in muscle tissue.
    • To compare muscle aromatase activity with that of adipose tissue.

    Main Methods:

    • Autopsy-obtained skeletal muscle samples from lower limbs of men and postmenopausal women were used.
    • In vitro conversion assays measured the transformation of tritiated androstenedione to estrogen.

    Related Experiment Videos

  • Estrogen production was quantified in picograms per gram of wet weight (pg/g wet wt).

    • Main Results:

    • Skeletal muscle homogenates from both men and postmenopausal women demonstrated significant aromatase activity.
    • Estrogen production ranged from 8.5-39.8 pg/g wet wt in the studied muscle samples.
    • The measured estrogen conversion rates in muscle were comparable to those previously reported for human adipose tissue.

    Conclusions:

    • This study provides the first direct confirmation of aromatase activity within human skeletal muscle.
    • Muscle tissue represents a potentially significant extragonadal source of estrogen production in men and postmenopausal women.
    • The contribution of muscle to extraglandular estrogen synthesis may be similar to that of adipose tissue.