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Estradiol and hemodynamics during ovulation induction.

J C Veille, M J Morton, K Burry

The Journal of Clinical Endocrinology and Metabolism

|September 1, 1986

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Elevated estrogen levels in women significantly increase left ventricular size and stroke volume, mimicking cardiovascular changes seen in pregnancy. These rapid adaptations highlight estrogen

Area of Science:

Cardiovascular Physiology
Reproductive Endocrinology

Background:

Pregnancy and estrogen administration in animals increase left ventricular size and stroke volume.
Human pregnancy involves significant cardiovascular adaptations.

Purpose of the Study:

To investigate if elevated endogenous estrogens in humans induce hemodynamic changes similar to pregnancy.
To correlate endogenous estrogen levels with cardiovascular parameters.

Main Methods:

Studied 14 patients undergoing ovulation induction.
Measured serum estradiol and used M-mode echocardiography at different cycle phases.
Assessed left ventricular dimensions, stroke volume, cardiac index, heart rate, blood pressure, and systemic vascular resistance.

Main Results:

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Serum estradiol levels significantly increased from the proliferative phase to midcycle.
A significant increase in left ventricle diastolic dimension (2.3 mm) was observed.
Stroke volume and cardiac index increased, while systemic vascular resistance decreased; heart rate and blood pressure remained unchanged.

Conclusions:

High endogenous estrogen levels rapidly induce cardiovascular changes, including increased left ventricular size, similar to pregnancy adaptations.
These estrogen-induced changes occur within days, suggesting a key role in maternal cardiovascular adaptation.
Endogenous estrogen levels correlate significantly with left ventricular size and other cardiovascular parameters.