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Published on: May 12, 2023
Chronic neutropenia in adults
Sara Kristina Viberg Tjønnfjord1, Maryan Mohamed Ali2, Geir E Tjønnfjord2
1Avdeling for blodsykdommer, Oslo universitetssykehus, og, Nefrologisk avdeling, Odense universitetssykehus.
Abstract:
Neutrophils are an important component of the innate immune system, and they prevent bacterial and fungal infections by phagocytosis and killing of pathogens. Neutropenia is defined as an abnormally low number of circulating neutrophils, and the term chronic neutropenia is used when it lasts more than three months. The objective of this clinical review is to raise awareness among doctors in Norway of chronic neutropenia and possible causes. A patient with severe neutropenia and fever requires immediate admission to hospital and initiation of empiric sepsis treatment before the cause of neutropenia has been determined, but patients with chronic neutropenia do not always require rapid and extensive workup.
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