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Mesoporous Polydopamine-Encapsulated Fluorescent Nanodiamonds: A Versatile Platform for Biomedical Applications
Hak-Sung Jung1,2, Kyung-Jin Cho3, Sihwa Joo4
1Laboratory of Single Molecule Biophysics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
ACS Applied Materials & Interfaces
|June 21, 2023
Summary
Mesoporous polydopamine encapsulation enhances fluorescent nanodiamonds (FNDs) for biomedical uses. This functionalization enables advanced cellular imaging, microRNA detection, and targeted cancer therapy delivery.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Fluorescent nanodiamonds (FNDs) offer unique optical properties for biomedical applications.
- Efficient surface functionalization of FNDs is critical but remains a significant challenge for their effective use.
Purpose of the Study:
- To develop a novel method for functionalizing FNDs using mesoporous polydopamine (mPDA) encapsulation.
- To explore the utility of functionalized FNDs for cellular imaging, diagnostics, and drug delivery.
Main Methods:
- FNDs were encapsulated within a mesoporous polydopamine (mPDA) shell via self-assembly of Pluronic F127 and dopamine hydrochloride polymerization.
- The mPDA shell was functionalized with various polymers (mPEG-SH, HPG, TPGS) and an oligonucleotide.
- Drug loading and cellular uptake studies were performed using HeLa cells and doxorubicin hydrochloride.
Main Results:
- Successfully synthesized FND@mPDA nanoparticles with a functionalizable mesoporous shell.
- PEGylated FND@mPDA demonstrated efficient cellular uptake for fluorescent imaging.
- HPG-functionalized FND@mPDA enabled microRNA detection via hybridization.
- TPGS-modified FND@mPDA exhibited enhanced doxorubicin loading and potent cancer cell toxicity.
Conclusions:
- Mesoporous polydopamine encapsulation provides a versatile platform for FND functionalization.
- Functionalized FND@mPDA nanoparticles show significant potential for advanced biomedical applications, including diagnostics and targeted cancer therapy.
