Glucose variability: a new risk factor for cardiovascular disease
Martina Belli1,2, Alfonso Bellia3, Domenico Sergi1
1Division of Cardiology, Department of Systems Medicine, Tor Vergata University, 00133, Rome, Italy.
Acta Diabetologica
|June 21, 2023
Summary
Glucose variability (GV) is a key indicator of glycemic control linked to diabetic vascular complications. Further research is needed to establish a gold standard for measuring GV and identify optimal treatments.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Vascular Biology
Background:
- Glucose variability (GV) is emerging as a critical metric in diabetes management.
- Increasing evidence links GV to the development of diabetic vascular complications.
Purpose of the Study:
- To review the definition and significance of GV in diabetes.
- To explore the relationship between GV, atherosclerosis, and diabetic complications.
Main Methods:
- Literature review on glucose variability parameters.
- Analysis of pathogenetic mechanisms of atherosclerosis in diabetes.
- Synthesis of evidence linking GV to diabetic vascular complications.
Main Results:
- GV is recognized as an important index of glycemic control.
- Multiple parameters exist for measuring GV, but a gold standard is lacking.
- GV is associated with increased risk of diabetic vascular complications.
Conclusions:
- GV plays a significant role in the pathophysiology of diabetic vascular complications.
- Further research is essential to standardize GV measurement and determine optimal therapeutic strategies.
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