Bizarre blue nevus: a case report with deoxyribonucleic acid content analysis

Area of Science:

• Dermatopathology
• Oncology
• Cytogenetics

Background:

• Blue nevus is a benign melanocytic proliferation.
• Atypical variants can mimic malignancy.
• Distinguishing benign from malignant lesions is crucial for patient management.

Observation:

• A case of an unusual blue nevus variant with significant cytologic atypia is presented.
• The lesion lacked definitive clinical and histologic signs of malignancy.
• Comparison with atypical blue nevus and Spitz nevus was performed.

Findings:

• Deoxyribonucleic acid (DNA) analysis revealed polyploidy in lesional cells.
• This finding supports an atypical interpretation of the nevus.
• The polyploidy is not inconsistent with a benign diagnosis.

Implications:

• This case expands the spectrum of blue nevus variants.
• Understanding cytologic atypia and DNA content aids in diagnosis.
• Further research may clarify the behavior of such atypical nevi.