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Related Experiment Videos

Granulomatous tertiary syphilis.

J L Tanabe, A C Huntley

    Journal of the American Academy of Dermatology
    |August 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Tertiary syphilis can manifest with severe neurological and dermatological symptoms, including organic brain syndrome and distinctive skin lesions. This case highlights that syphilis remains a relevant clinical diagnosis, even in its late stages.

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    Area of Science:

    • Neurology
    • Dermatology
    • Infectious Diseases

    Background:

    • Tertiary syphilis is a late stage of syphilis infection, often characterized by severe neurological or cardiovascular complications.
    • Neurosyphilis can present with a wide range of cognitive and psychiatric symptoms.
    • Cutaneous manifestations in tertiary syphilis are less common but can be diverse.

    Observation:

    • A 65-year-old woman developed progressive acute organic brain syndrome.
    • She also presented with peculiar scarring skin lesions.
    • Skin biopsy showed a deep dermal infiltrate of lymphocytes and granulomas.

    Findings:

    • Serologic testing confirmed syphilis.
    • The patient's positive response to treatment further supported the diagnosis.

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  • The clinical presentation was consistent with tertiary syphilis.
  • Implications:

    • This case underscores the importance of considering syphilis in the differential diagnosis of organic brain syndrome and unusual skin lesions.
    • It serves as a reminder that tertiary syphilis, though less common, is still an extant clinical entity.
    • Early diagnosis and treatment are crucial to prevent irreversible complications of syphilis.