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Exogenous ochronosis resulting from quinine injections
Journal of the American Academy of Dermatology
|August 1, 1986
Summary
Localized exogenous ochronosis, a skin condition, can result from quinine injections. This case highlights a rare complication of antimalarial therapy, presenting as bluish black macules.
Area of Science:
- Dermatology
- Pathology
Background:
- Exogenous ochronosis is a rare condition characterized by pigment deposition in the dermis.
- It has been associated with topical phenol, hydroquinone, and oral antimalarials.
Observation:
- An 86-year-old woman presented with asymptomatic bluish black macules on her buttocks.
- Skin biopsy confirmed the presence of ochronotic pigment in the dermis.
Findings:
- The patient had a history of quinine injections for malaria 70 years prior.
- Alkaptonuria was ruled out via urine testing.
- The diagnosis of localized exogenous ochronosis attributed to quinine injections was made.
Implications:
- This case represents the first reported instance of exogenous ochronosis following intramuscular antimalarial injections.
- It expands the known spectrum of iatrogenic causes for exogenous ochronosis.
- Clinicians should consider prior antimalarial injections in the differential diagnosis of ochronotic skin lesions.