Related Experiment Video
Updated: Jul 26, 2025
05:22
Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
1.4K
Iris color as a predictive factor for intraoperative floppy iris syndrome.
Margarita Safir1,2, Eran Greenbaum3,4, Maya Atar Vardi5,3
1Ophthalmology Department, Shamir (Assaf-Harofeh) Medical Center, 70300, Zerifin, Israel. safir.margarita@gmail.com.
Summary
Patients with light-colored irises, such as blue or green, have a significantly higher risk of developing intraoperative floppy iris syndrome (IFIS) during cataract surgery. This increased risk extends to the severity and bilaterality of IFIS.
Area of Science:
- Ophthalmology
- Surgical Science
Background:
- Intraoperative floppy iris syndrome (IFIS) is a complication during cataract surgery.
- The role of iris color in IFIS predisposition is not fully understood.
Purpose of the Study:
- To investigate the association between iris color and the risk of developing IFIS.
- To determine if iris color influences the severity and bilaterality of IFIS.
Main Methods:
- Retrospective review of 155 patients undergoing cataract surgery.
- Exclusion of patients with specific pre-existing ocular conditions.
- Assessment of iris color and IFIS occurrence, severity, and bilaterality using statistical analyses.
Main Results:
- Blue irises showed a 4.50-fold risk, and green irises a 7.00-fold risk for IFIS compared to brown irises.
- Light iris colors were associated with increased IFIS severity and bilaterality.
- These associations remained statistically significant after adjusting for confounders.
Conclusions:
- Light iris color is a significant risk factor for IFIS occurrence during cataract surgery.
- Iris color influences IFIS severity and the likelihood of bilateral occurrence.
- Ophthalmologists should consider iris color when assessing IFIS risk.
