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A Case of Abdominal Perforation in a COVID+ Patient Treated With Tocilizumab and Corticosteroids

Bilal Chaudhry1, Kirill Alekseyev2, Lidiya Didenko2

  • 1Christiana Care Health System, Newark, DE, USA.

Clinical Medicine Insights. Case Reports
|June 21, 2023
PubMed

Insights

Tocilizumab may increase the risk of abdominal perforation in COVID-19 patients, particularly when combined with steroids. Steroids can mask symptoms, making diagnosis of this serious complication more difficult.

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Pharmacology

Background:

  • Coronavirus Disease 2019 (COVID-19) can lead to severe pneumonia.
  • Several treatments are approved for severe COVID-19, including tocilizumab and corticosteroids.
  • Gastrointestinal tract involvement in COVID-19 is a recognized phenomenon.

Keywords:
COVIDGI perforationimmunosuppressive effectsmasked presentationtocilizumab use

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