Comprehensive Landscape of Modules-Dysregulated Functions Reveals a Profound Role of ceRNAs in Coronary Heart Disease
Chen Chen1, Li Wang2, Qiuju Feng1
1Institute of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Insights
This study reveals key competitive endogenous RNA (ceRNA) network alterations in coronary heart disease (CHD). The findings identify specific ceRNA functions, offering insights into CHD mechanisms and potential biomarkers.
Area of Science:
- Biochemistry
- Genetics
- Molecular Biology
Background:
- Coronary heart disease (CHD) is a leading cause of cardiovascular mortality.
- Competitive endogenous RNAs (ceRNAs) are implicated in complex diseases, but their role in CHD is not fully understood.
Purpose of the Study:
- To systematically analyze ceRNA alterations in CHD.
- To identify specific dysregulated ceRNA network modules and their associated functions in CHD.
- To uncover potential diagnostic and therapeutic biomarkers for CHD.
Main Methods:
- Differential gene and lncRNA expression analysis.
- Construction of a ceRNA regulatory network.
- Identification and functional enrichment analysis of dysregulated modules.
Main Results:
- Identified 2457 differentially expressed genes and 212 differentially expressed lncRNAs.
- Constructed a ceRNA network with extensive regulatory relationships.
- Revealed CHD-specific functions including histone acetylation and platelet degranulation.
Conclusions:
- The study elucidates the role of ceRNAs in CHD pathogenesis.
- Identified dysregulated ceRNA modules provide novel insights into CHD mechanisms.
- Findings facilitate the discovery of potential diagnostic and therapeutic targets for CHD.
Abstract:
Coronary heart disease (CHD) is one of the most common severe cardiovascular diseases. Competitive endogenous RNAs (ceRNA) play critical roles in complex diseases. However, our understanding of the dysregulated functions of ceRNAs in CHD remains limited. Here, we systematically analyzed the alterations of ceRNAs and identified the specific functions based on dysregulated modules from the ceRNA network. A total of 2457 significantly differential expressed genes and 212 differential expressed lncRNAs were identified. We got 76679 regulator relationship between different expression genes and miRNAs and 336 regulator relationship between differential expressed lncRNAs and miRNAs. We constructed the ceRNA network and selected five dysregulated modules. Furthermore, CHD specific functions based on dysregulated modules from the ceRNA network were identified, including histone acetylation, platelet degranulation, cAMP-dependent protein kinase complex, xenobiotic transport and so on. Our results will provide novel insight for a better understanding of the mechanism of ceRNAs and facilitate the identification of novel diagnostic and therapeutic biomarkers in CHD.
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