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Classification of human chronotype based on fMRI network-based statistics.

Sophie L Mason1,2, Leandro Junges2, Wessel Woldman2

  • 1School of Mathematics, College of Engineering and Physical Sciences, University of Birmingham, Birmingham, United Kingdom.

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Chronotype, or an individual's internal body clock, influences brain networks. Extreme chronotypes show distinct functional brain network differences, impacting cognition and mental health.

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chronotype (morningness-eveningness)classifierfMRIfunctional connectivityfunctional networksgraph theorynetwork-based statistical (NBS) analysis

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Cognitive Science

Background:

  • Chronotype, the alignment of internal circadian rhythms with the 24-hour light-dark cycle, is linked to mental health and cognitive function.
  • Late chronotypes are associated with higher depression risk and impaired cognitive performance during typical work hours.
  • The neural basis connecting circadian physiology, brain networks, cognition, and mental health remains unclear.

Purpose of the Study:

  • To investigate if functional brain networks contain information differentiable by chronotype.
  • To determine how chronotype-related brain network differences change throughout the day.
  • To explore the potential of brain network analysis for classifying extreme chronotypes.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (rs-fMRI) data from 16 early and 22 late chronotype individuals.
  • Developed a classification framework using Network Based-Statistics (NBS) to analyze brain network differences.
  • Collected data across three scanning sessions to assess temporal changes.

Main Results:

  • Identified distinct subnetworks that differ between extreme chronotypes at various times of day.
  • Achieved high classification accuracy (97.3%) for distinguishing chronotypes in the evening.
  • Demonstrated that classification accuracy varies across scanning sessions, highlighting temporal dynamics.

Conclusions:

  • Functional brain network differences are associated with extreme chronotypes.
  • These findings suggest that chronotype is embedded within brain network organization.
  • Further research can elucidate the relationship between physiology, brain networks, and mental health conditions.