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Related Experiment Video

Updated: Jul 26, 2025

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

Published on: November 4, 2014

Full-view LED-based optoacoustic tomography.

Xiang Liu^1,2, Sandeep Kumar Kalva^1,2, Berkan Lafci^1,2

¹Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich CH-8057, Switzerland.

|June 21, 2023

Summary

This summary is machine-generated.

A new full-view LED-based optoacoustic tomography (FLOAT) system offers a cost-effective alternative for deep tissue imaging. This portable system demonstrates comparable performance to traditional lasers, enhancing accessibility for various applications.

Keywords:

Laser Light emitting diode Low-cost light sources Optoacoustic/photoacoustic tomography

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Universal Hand-held Three-dimensional Optoacoustic Imaging Probe for Deep Tissue Human Angiography and Functional Preclinical Studies in Real Time

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Multispectral Optoacoustic Tomography for Functional Imaging in Vascular Research

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Published on: June 8, 2022

Area of Science:

Biomedical Optics
Medical Imaging Technology
Acoustic Imaging

Background:

Optoacoustic tomography typically relies on bulky, expensive lasers.
Light-emitting diodes (LEDs) offer a portable and cost-effective alternative for optoacoustic excitation.
Existing systems face limitations in field-of-view and image quality for deep tissue imaging.

Purpose of the Study:

Introduce a full-view LED-based optoacoustic tomography (FLOAT) system for deep tissue in vivo imaging.
To provide a cost-effective, portable, and stable illumination source for optoacoustic tomography.
To enhance image quality and circumvent limited-view effects in cross-sectional imaging.

Main Methods:

Developed a custom electronic unit to drive a stacked array of LEDs for optoacoustic signal excitation.
Integrated the LED array with a circular array of cylindrically-focused ultrasound detectors for a full-view tomographic configuration.
Characterized system performance including pulse width, power stability, light distribution, signal-to-noise ratio, and penetration depth.

Main Results:

The FLOAT system achieved a 100 ns pulse width and 0.48 mJ per-pulse energy with high stability (0.62% std dev).
Full-view configuration effectively addressed limited-view effects, improving field-of-view and image quality.
Imaging of a human finger showed performance comparable to standard pulsed Nd:YAG lasers.

Conclusions:

The FLOAT system presents a compact, affordable, and versatile illumination technology for optoacoustic imaging.
This LED-based approach can significantly advance optoacoustic imaging in resource-limited settings.
FLOAT technology holds promise for broader biological and clinical applications.