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Related Experiment Video

Updated: Jul 26, 2025

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Caruncle dysgeneses - A case series.

Cornelius Jakob Wiedenmann1, Thomas Reinhard1, Claudia Auw-Hädrich1

  • 1Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.

American Journal of Ophthalmology Case Reports
|June 21, 2023
PubMed
Summary
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Caruncle dysgeneses are rare eyelid conditions that require differentiation from tumors. This case series details five instances, including histopathological findings, aiding diagnosis and management of these uncommon eyelid anomalies.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Pathology

Background:

  • Caruncle dysplasias are exceedingly rare congenital abnormalities of the ocular adnexa.
  • Distinguishing these from caruncular and conjunctival tumors is crucial for appropriate patient management.
  • Limited histopathological data exists for caruncle dysplasias, necessitating further case reporting.

Observation:

  • This case series presents four patients with five caruncle dysplasias, including two with detailed histopathological examinations.
  • Case 1: A supernumerary caruncle in a young woman, histopathologically showing non-keratinizing squamous epithelium with goblet cells and subepithelial inflammation.
  • Case 2: A megacaruncle in an older woman, exhibiting similar histopathological features with focal keratinization.

Findings:

Keywords:
Caruncle tumourConjunctivaDysgenesesOcular adnexaOphthalmic pathology

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  • Histopathology revealed non-keratinizing squamous epithelium with goblet cells, lymphoplasmacytic infiltration, epidermal cysts, sebaceous glands, and adipose tissue.
  • Absence of hair follicles, sweat glands, or lacrimal glands was noted in the dysplastic caruncle tissue.
  • Clinical diagnoses included supernumerary caruncle and megacaruncle, with one patient diagnosed with Goldenhar syndrome.
  • Implications:

    • Caruncle dysplasias can be asymptomatic and mimic tumors, underscoring the need for careful differential diagnosis.
    • Association with oculo-auriculo-vertebral spectrum disorders like Goldenhar syndrome should be considered.
    • Excision and histopathological examination are recommended for ambiguous cases or symptomatic lesions.