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Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

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33
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
33

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Related Experiment Video

Updated: Jul 26, 2025

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Common Design and Data Elements Reported on Idiopathic Intracranial Hypertension Trials: A Systematic Review.

Hassan Kobeissi1, Cem Bilgin, Sherief Ghozy

  • 1Departments of Radiology (HK, CB, SG, WB, RK, DFK), Ophthalmology (TX, JJC), and Neurologic Surgery (RK), Mayo Clinic, Rochester, Minnesota; Department of Radiology (GA), Massachusetts General Hospital, Boston, Massachusetts; Nested Knowledge (JT, NH, RT, KMK), St Paul, Minnesota; Department of Neurology (AS), University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, United Kingdom; Translational Brain Science (AS, SPM), Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom; and Birmingham Neuro-Ophthalmology (SPM), University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, United Kingdom.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|June 21, 2023
PubMed
Summary

Idiopathic intracranial hypertension (IIH) trials lack consistent design and data elements, hindering future research synthesis. Establishing consensus on trial design is crucial for advancing patient care and effective meta-analyses in IIH research.

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Area of Science:

  • Neurology
  • Clinical Trials
  • Ophthalmology

Background:

  • Idiopathic intracranial hypertension (IIH) management research is expanding with numerous clinical trials.
  • A Common Design and Data Element (CDDE) analysis was performed on existing IIH studies.
  • The goal is to standardize future trial designs and data collection for better synthesis.

Approach:

  • Searched PubMed and ClinicalTrials.gov for IIH treatment trials.
  • Utilized the Nested Knowledge AutoLit platform for data extraction.
  • Analyzed study outputs to assess data element homogeneity.

Key Points:

  • Modified Dandy criteria were the most common inclusion criteria (64%).
  • Change in visual function was the most common outcome measure (86%).
  • Surgical interventions were evaluated more frequently (64%) than medical therapies (43%).

Conclusions:

  • Significant inconsistencies exist in IIH trial inclusion criteria, exclusion criteria, and outcome measures.
  • Varied time frames for outcome assessment further complicate data synthesis.
  • A consensus on IIH trial design is an unmet research need to improve data comparability and meta-analysis effectiveness.